However, the VTOL meant to take them there is destroyed in an explosion, killing the Division Commander along with most of the second wave and severely wounding Faye Lau. Arriving in a JTF-commandeered news helicopter instead, the Division agents reclaim the James A. Farley Post Office Building as their base of operations. In the course of the game, the agent helps rescue important personnel like Dr. Jessica Kandel, Captain Roy Benitez and Paul Rhodes. These personnel head the Medical, Security and Tech wings of the base of operations respectively. Agents also recover a sample of Green Poison. Studying the sample reveals the virus was manufactured and then modified heavily by a controversial biologist named Dr. Gordon Amherst.

Eventually, the agents find footage of Division agent Aaron Keener going rogue and killing other agents, having gone insane after witnessing the chaos and destruction caused during the breakdown of order following the initial outbreak. It is also discovered Keener and the rest of the first wave of agents who went rogue along with him are assisting the “Last Man Battalion” (LMB), an equally rogue private military company that was abandoned by the government during the evacuation, and are now hostile to it. Working together, these two groups destroyed the VTOL and killed the Commander to weaken Division operations in New York. Intercepting a signal from the Russian consulate, the agents attempt to rescue Vitaly Tchernenko, a Russian virologist who claims to have information on the Green Poison.



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